Description

Exemestane Tablets 25 mg – Aromatase Inhibitor for Breast Cancer Treatment

Exemestane Tablets 25 mg are prescription-strength medications used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. The tablets work by inhibiting the enzyme aromatase, responsible for converting androgens into estrogens in the body.

By significantly reducing estrogen levels, Exemestane limits the hormonal stimulus needed for the growth of estrogen-dependent cancer cells. It is used both as early-stage adjuvant therapy and in advanced or metastatic disease, especially in patients previously treated with tamoxifen.

Key Features of Exemestane 25 mg

• Aromatase Inhibitor: Suppresses estrogen production
• Breast Cancer Use: For both early and advanced stages
• Used After Tamoxifen Resistance: Helps when prior treatments fail
• Oral Administration: Easy and convenient daily dosage
• Selective Action: Lowers estrogen without affecting other hormones

Therapeutic Indications

1. Adjuvant treatment of postmenopausal women with early breast cancer after 2-3 years of tamoxifen therapy
2. First-line treatment for advanced hormone receptor-positive breast cancer
3. Second-line therapy for progressive metastatic breast cancer unresponsive to previous hormone therapy
4. May also be used in combination with other agents in specific treatment regimens

Exemestane has been proven to extend disease-free intervals and lower the risk of recurrence in early-stage hormone-driven cancers.

Mechanism of Action

Exemestane is an irreversible aromatase inhibitor, meaning it permanently deactivates the aromatase enzyme. This action blocks the conversion of adrenal androgens into estrogens, leading to a significant drop in circulating estrogen levels.

Since many breast tumors rely on estrogen to grow, reducing estrogen slows or halts tumor progression. This hormonal suppression is vital in postmenopausal women, where most estrogen is derived from peripheral conversion rather than ovarian production.

Dosage and Administration

• Typical Dose: 25 mg taken once daily, preferably after a meal
• Form: Oral tablet, to be swallowed whole
• Timing: Take at the same time each day to maintain consistent blood levels
• Treatment Duration: Depends on the stage, medical history, and doctor’s judgment. Often continued for 2 to 5 years or longer in certain cases

Note: Do not abruptly stop the medication without medical advice, as it may affect treatment efficacy.

Possible Side Effects

Most side effects of Exemestane are mild to moderate and decrease with continued use or supportive care. However, report any severe or persistent reactions to your healthcare provider.

Common Side Effects Include:

• Hot flashes
• Night sweats
• Fatigue or dizziness
• Joint or muscle pain
• Nausea
• Headache
• Depression or mood changes
• Increased sweating
• Insomnia
• Loss of appetite

Serious Side Effects May Include:

• Osteoporosis or bone fractures
• Liver enzyme elevation
• Chest pain or difficulty breathing
• Allergic reactions (rare)
• Visual changes

Routine health monitoring may include bone density tests, liver function tests, and lipid profiles.

Drug Warnings and Precautions

• Not recommended in premenopausal women unless under specialist advice
• Do not use during pregnancy or breastfeeding
• Notify your doctor if you have osteoporosis, liver disease, or high cholesterol
• Do not use with estrogen-containing therapy (e.g., HRT or contraceptives)
• Caution if you drive or operate machinery until you know how the drug affects you
• Continue regular check-ups with your oncologist or gynecologist

Drug Interactions

• Avoid use with estrogen-based replacement therapy as it reverses the effect
• May interact with CYP3A4 inducers like rifampicin, carbamazepine, or phenytoin, which may reduce effectiveness
• Always inform your doctor of all medications or supplements you’re taking

Storage Instructions

• Store at 20°C to 25°C (68°F to 77°F)
• Protect from moisture, heat, and light
• Keep in the original packaging until use
• Store medicine out of reach of children and pets
• Do not use if the packaging is damaged or expiration date has passed

Why Buy Exemestane 25 mg From Us?

• Licensed pharmacy sourcing from verified manufacturers
• Guaranteed 100% authentic product with batch tracking
• Competitive pricing and bulk availability
• Private packaging with safe delivery
• Responsive customer support to assist with orders and inquiries
• Fast, secure shipping for domestic and international orders

Frequently Asked Questions (FAQs)

1. What are Exemestane Tablets 25 mg used for?
Exemestane is used for treating hormone receptor-positive breast cancer in postmenopausal women, particularly after treatment with tamoxifen.

2. Is Exemestane a type of chemotherapy?
No, Exemestane is a form of hormone therapy known as an aromatase inhibitor. It is not cytotoxic like traditional chemotherapy drugs.

3. Can Exemestane be used in premenopausal women?
It is typically prescribed for postmenopausal women. In some cases, it may be used with ovarian suppression in premenopausal women, but this is under specialist care.

4. How long should you take Exemestane tablets?
Duration varies. Treatment may continue for several years depending on cancer type, stage, and patient response.

5. What should I do if I miss a dose?
Take it as soon as you remember, unless it’s nearly time for the next dose. Do not take two doses at once.

6. Can Exemestane affect bones?
Yes. Long-term use may cause decreased bone mineral density. Doctors often monitor bone health during treatment.

7. Are there any dietary restrictions with Exemestane?
No specific foods are restricted, but a calcium and vitamin D-rich diet is advised to protect bone health.

8. Is a prescription required to buy Exemestane 25 mg?
Yes, it is a prescription-only medication and should be taken under medical supervision.

9. Is Exemestane safe during pregnancy or breastfeeding?
No. Do not use during pregnancy or breastfeeding. Inform your doctor if you are planning to conceive.

10. Can Exemestane be taken with other medications?
Some medications may interfere with how Exemestane works. Always inform your doctor about any current medications.