Description

Enzalutamide Capsules 80 mg

Enzalutamide 80 mg is an oral anti-cancer medication used primarily for the treatment of advanced prostate cancer, including metastatic castration-resistant prostate cancer (mCRPC) and non-metastatic castration-resistant prostate cancer (nmCRPC). It belongs to the class of medications known as androgen receptor inhibitors, which work by blocking the action of androgens (male hormones) that stimulate the growth of prostate cancer cells.

This 80 mg strength formulation is often preferred to reduce the total daily capsule count for patients, especially when a full daily dose of 160 mg (standard dose) is prescribed. It enhances patient compliance while maintaining therapeutic efficacy.

Brand Reference: Xtandi
Generic Name: Enzalutamide
Dosage Form: Capsule
Strength: 80 mg

Indications

Enzalutamide 80 mg is indicated for the treatment of:

• Metastatic Castration-Resistant Prostate Cancer (mCRPC)
• Non-Metastatic Castration-Resistant Prostate Cancer (nmCRPC)
• Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Enzalutamide is typically used alongside surgical or medical castration therapy (testosterone suppression or LHRH analogs).

Mechanism of Action

Enzalutamide 80 mg works by:

• Blocking the androgen receptor (AR) at multiple steps in the signaling pathway
• Inhibiting the binding of androgens like testosterone to the receptor
• Preventing the androgen-receptor complex from entering the cell nucleus
• Blocking interaction with DNA, thereby stopping cancer cell growth and division

This multi-level blocking action disrupts the chain of androgen-dependent tumor progression.

Dosage and Administration

• Standard Adult Dose: 160 mg once daily (typically as two 80 mg capsules)
• Route: Oral
• Administration: Can be taken with or without food
• Swallow capsules whole; do not chew, crush, or open

Enzalutamide should be continued until disease progression or until unacceptable side effects occur.

Note: Should be used along with ongoing hormone therapy to maintain castrate testosterone levels (<50 ng/dL).

Composition

• Active Ingredient: Enzalutamide 80 mg
• Excipients/Fillers: May include caprylocaproyl macrogolglycerides, butylated hydroxyanisole, gelatin, titanium dioxide, etc.
• Packaging: Typically stored in bottles or blister packs (28, 56, or 120 capsules)

Common Side Effects

• Fatigue
• Hot flashes
• Hypertension
• Headache
• Musculoskeletal pain
• Diarrhea
• Dizziness
• Decreased appetite

Serious Side Effects (seek medical attention)

• Seizures (rare but serious)
• Falls and fractures
• Cognitive impairment or memory issues
• Posterior Reversible Encephalopathy Syndrome (PRES)
• Severe hypertension or cardiovascular risk

Regular medical supervision and monitoring are advised during therapy.

Warnings and Precautions

• Seizure Risk: Avoid in patients with seizure history unless otherwise approved by a doctor
• Reproductive Toxicity: Enzalutamide can cause embryo-fetal toxicity; not for use in women or children
• Blood Pressure Monitoring: Required regularly during treatment
• Driving and Machinery: Avoid operating machinery if experiencing fatigue or dizziness due to medication
• Contraception: Male patients with partners of reproductive potential should use effective contraception during treatment and for 3 months after the last dose

Drug Interactions

• Interacts with drugs affecting CYP3A4, CYP2C8, and CYP2C19 enzyme systems
• Can increase exposure to drugs such as warfarin, phenytoin, and omeprazole
• Avoid CYP2C8 inhibitors (e.g., gemfibrozil) without professional advice
• Grapefruit may alter drug metabolism — avoid during treatment

Storage Instructions

• Store at temperature below 30°C (86°F)
• Keep away from heat, moisture, and direct sunlight
• Store in the original container and keep out of reach of children

Do not use expired capsules.

Frequently Asked Questions (FAQs)

1. What is Enzalutamide 80 mg used for?
It is used to treat prostate cancer that no longer responds to hormone therapy, including mCRPC, nmCRPC, and mCSPC.

2. Is 80 mg the usual dose?
The standard total dose is 160 mg once daily. The 80 mg capsule helps reduce pill burden (2 capsules vs. 4 capsules of 40 mg).

3. Can I take Enzalutamide 80 mg with food?
Yes. It can be taken with or without meals.

4. Does it require hormone therapy with it?
Yes. It is combined with medications or procedures that lower testosterone to castration levels.

5. What are the common side effects?
Fatigue, dizziness, high blood pressure, and hot flashes are the most common.

6. Can I drive while taking Enzalutamide?
If you experience dizziness, seizures, or impaired thinking, you should avoid driving or using machinery.

7. Is Enzalutamide used in women?
No. It is not approved for use in women and can cause significant fetal harm if taken during pregnancy.

8. How long do I continue taking this medicine?
You should continue until disease progression or until your healthcare provider recommends stopping due to side effects.

9. Are there pharmacokinetic interactions to be aware of?
Yes, especially with CYP2C8 and CYP3A4-metabolized drugs. Always provide your doctor with a full medication list.

10. Can I buy Enzalutamide 80 mg online?
Yes, from licensed pharmacies only. A valid prescription is required.