Palbociclib Capsules 100 Mg

Description

Buy Palbociclib 100 mg Online at Pinkline Exports

Palbociclib 100 mg is a medication used for the treatment of certain types of breast cancer. It is a chemotherapy drug classified as a CDK4/6 inhibitor. It is typically prescribed in combination with other treatments to slow the growth and division of cancer cells.

Composition

• Active Ingredient: Palbociclib
• Strength: 100 mg
• Form: Oral tablet

Indications

Palbociclib is primarily used for the treatment of hormone receptor-positive, HER2-negative breast cancer:

• Metastatic Breast Cancer: Palbociclib is used in combination with aromatase inhibitors (such as letrozole) for postmenopausal women or men with hormone receptor-positive, HER2-negative breast cancer.
• Advanced or Metastatic Breast Cancer: Used in combination with fulvestrant in patients who have previously received endocrine therapy.

How Palbociclib 100 mg Works?

Palbociclib works by inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6), which are key regulators of the cell cycle. By blocking these proteins, palbociclib prevents the progression of cancer cells through the cell cycle, ultimately inhibiting their growth and proliferation. This mechanism is particularly effective in treating hormone receptor-positive breast cancers.

Dosage and Administration

• Standard Dose: The typical starting dose for palbociclib is 100 mg taken orally once daily for 21 consecutive days followed by a 7-day rest period to complete a 28-day cycle.
• Dose Adjustments: The dosage may be reduced to 75 mg or 50 mg if the patient experiences significant side effects.
• How to Take: Palbociclib should be taken at the same time each day, with or without food. Swallow the tablet whole; do not crush or chew the tablet.

Important Considerations

• Missed Dose: If you miss a dose, take it as soon as possible unless it is almost time for your next dose. Do not take two doses at once to make up for a missed dose.
• Consistency: Take the medication consistently, and do not stop or alter the dosage without consulting your healthcare provider.

Side Effects

Common side effects of palbociclib include:

• Low Blood Counts (Myelosuppression): Decreased levels of white blood cells (neutropenia), red blood cells (anemia), and platelets (thrombocytopenia) are common. This can increase the risk of infections, fatigue, and bleeding.
• Fatigue
• Mouth sores
• Diarrhea
• Nausea
• Hair thinning or hair loss

Serious Side Effects:

• Infections: Palbociclib can lower white blood cell counts, increasing the risk of serious infections such as fever, chills, or severe sore throat.
• Liver problems: Symptoms such as yellowing of the skin or eyes, dark urine, or abdominal pain may indicate liver issues.
• Breathing problems: Shortness of breath, cough, or chest pain can be signs of lung issues that should be addressed immediately.

Precautions and Warnings

• Blood Cell Counts: Regular monitoring of blood counts is required because palbociclib can significantly lower white blood cells, red blood cells, and platelets.
• Liver Function: Liver function tests should be conducted regularly as palbociclib can affect the liver.
• Pregnancy and Breastfeeding: Palbociclib is contraindicated during pregnancy and breastfeeding due to the risk of harm to the fetus or infant.
• Drug Interactions: Be cautious when taking other medications that affect the liver enzyme CYP3A. For example, grapefruit and grapefruit juice can interfere with how palbociclib is processed in the body, potentially increasing side effects.

Drug Interactions

Palbociclib can interact with several other medications, including:

• CYP3A inhibitors (e.g., ketoconazole, ritonavir): These drugs can increase palbociclib levels and may require dose adjustment.
• CYP3A inducers (e.g., rifampin, phenytoin): These drugs can decrease palbociclib’s effectiveness and may require alternative treatments.

Palbociclib 100 mg is an effective treatment for hormone receptor-positive, HER2-negative breast cancer, particularly in metastatic or advanced stages. It works by inhibiting key proteins that regulate cell division, which helps slow the progression of cancer. However, regular monitoring of blood counts and liver function is necessary to ensure the drug’s safety and effectiveness. Always follow your healthcare provider’s instructions and attend scheduled check-ups for optimal treatment management.

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