Palbociclib Capsules 125 Mg

Description

Buy Palbociclib 125 mg Online at Pinkline Exports

Palbociclib 125 mg is a medication used in the treatment of certain types of breast cancer. It is an oral chemotherapy drug that belongs to the class of medications known as CDK4/6 inhibitors. Palbociclib is commonly prescribed in combination with other treatments to help slow the growth of cancer cells.

Composition

• Active Ingredient: Palbociclib
• Strength: 125 mg
• Form: Oral tablet

Indications

Palbociclib is primarily used to treat hormone receptor-positive, HER2-negative breast cancer in the following conditions:

• Metastatic Breast Cancer: In combination with an aromatase inhibitor (e.g., letrozole) as initial treatment for postmenopausal women, or in combination with letrozole for men.
• Advanced or Metastatic Breast Cancer: In combination with an aromatase inhibitor (such as letrozole) or fulvestrant in patients who have previously been treated with endocrine therapy.

How Palbociclib 125 mg Works

Palbociclib works by inhibiting cyclin-dependent kinases (CDK) 4 and 6, which are proteins involved in regulating the cell cycle. By blocking these kinases, palbociclib prevents cancer cells from dividing and growing, thus slowing the progression of the cancer. This effect is especially useful in treating hormone receptor-positive breast cancers, which rely on these growth signals.

Dosage and Administration

• Initial Dose: The usual dose of palbociclib is 125 mg taken orally once daily for 21 days followed by 7 days off to complete a 28-day cycle.
• Adjustments: Based on your individual response and tolerance, the dose may be adjusted (e.g., to 100 mg or 75 mg) if side effects occur.
• Administration: Take palbociclib with or without food, but it is important to take it consistently at the same time each day to help remember.

Important Considerations

• Missed Dose: If a dose is missed, take it as soon as you remember unless it is almost time for the next dose. Do not take two doses at once to make up for a missed dose.
• Duration of Treatment: The treatment duration is typically determined by the patient’s response to the medication. It may continue as long as the patient benefits from it and side effects are manageable.

Side Effects

Common side effects associated with palbociclib include:

• Low Blood Cell Counts (Myelosuppression): This is the most common side effect and can lead to:
  • Neutropenia (low white blood cell count)
  • Anemia (low red blood cell count)
  • Thrombocytopenia (low platelet count)

Other possible side effects:

• Fatigue
• Nausea
• Mouth sores
• Diarrhea
• Infections
• Hair thinning or loss

Serious Side Effects:

• Lung problems: Signs may include shortness of breath, cough, and chest pain.
• Liver problems: Symptoms such as yellowing of the skin or eyes, dark urine, or severe abdominal pain.
• Severe infections: Symptoms like fever, chills, or pain while urinating.

Precautions and Warnings

• Blood Counts: Regular monitoring of blood counts (including white blood cells, red blood cells, and platelets) is important during treatment, as palbociclib can cause significant decreases in blood cell counts.
• Liver Function: Liver tests should be done regularly since palbociclib can affect liver function.
• Pregnancy and Breastfeeding: Palbociclib should not be used during pregnancy due to potential harm to the fetus. It is also not recommended during breastfeeding.
• Interactions with Other Drugs: Certain medications can interact with palbociclib, including drugs that affect the liver enzyme CYP3A. For instance, grapefruit and grapefruit juice should be avoided as they can affect how the medication is metabolized.

Drug Interactions

Palbociclib can interact with other medications, including:

• Strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, ritonavir) can increase the blood levels of palbociclib, requiring dose adjustments.
• Strong CYP3A inducers (e.g., rifampin, phenytoin) can reduce the effectiveness of palbociclib and should be avoided.

Palbociclib 125 mg is an important treatment option for patients with hormone receptor-positive, HER2-negative breast cancer, particularly in the metastatic or advanced stages. It works by inhibiting specific proteins involved in cell division, helping to slow the growth of cancer cells. Regular monitoring and attention to side effects, especially concerning blood counts and liver function, are important to ensure safe and effective treatment. Always consult a healthcare provider for proper management and monitoring during treatment.

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