Description

Abiraterone Acetate Tablets 500 Mg – Advanced Treatment for Prostate Cancer

Overview

Abiraterone Acetate 500 mg is a life-extending treatment for men with advanced prostate cancer, specifically metastatic castration-resistant prostate cancer (mCRPC). This form of prostate cancer continues to progress even when testosterone levels are reduced to extremely low levels (medically castrated).

Abiraterone 500 mg works by inhibiting the activity of CYP17, an enzyme necessary for the production of androgens (male hormones like testosterone) in the body. Since androgens can fuel the growth of prostate cancer cells, suppressing their production can slow or halt progression of the disease.

Key Features and Benefits

• High-Strength Dose: Fewer tablets required daily compared to traditional 250 mg versions.
• Generic Version of Zytiga: Offers the same active ingredient and therapeutic effects at a lower cost.
• Taken with Prednisone: Reduces risk of corticosteroid-related side effects and enhances efficacy.
• Oral Administration: Easy-to-take tablet, swallowed whole with water.
• GMP Certified Manufacturing: Produced in certified, high-quality pharmaceutical facilities.

Mechanism of Action

Abiraterone Acetate interferes with androgen biosynthesis by blocking CYP17A1 enzyme activity. This dual-function enzyme plays roles in both adrenal and testicular androgen production. Inhibiting CYP17 reduces blood levels of testosterone, which can deprive prostate cancer cells of necessary fuel, stopping or slowing tumor growth.

When combined with prednisone, it also helps manage the body’s reaction to androgen suppression, helping maintain a reliable treatment pathway while managing fluid balance, inflammation, and other hormone-mediated effects.

Recommended Usage

• Dosage: One 500 mg tablet taken once daily, on an empty stomach (no food 2 hours before or 1 hour after taking).
• Co-Therapy: Typically prescribed with prednisone 5 mg, twice daily.
• Duration: As determined by oncologist based on treatment response and disease progression.
• Do Not Crush or Split: Tablets must be swallowed whole with water.

Safety Information

Patients must undergo evaluations before and during treatment to monitor liver function, blood pressure, and potassium levels. Routine PSA (prostate-specific antigen) tests are also key to tracking treatment progress.

Common Side Effects:

• High blood pressure (hypertension)
• Low potassium
• Liver enzyme abnormalities
• Joint pain or swelling
• Fatigue
• Fluid retention

Serious Side Effects (rare but require immediate attention):

• Liver toxicity
• Adrenal insufficiency
• Cardiac arrhythmia

Storage Instructions

• Keep at room temperature (20–25°C or 68–77°F).
• Protect from moisture, heat, and direct sunlight.
• Store in original packaging.
• Keep out of reach of children and pets.

Who Should Not Take Abiraterone Acetate

• Women (especially those who are pregnant or may become pregnant)
• Children and adolescents
• Patients with severe liver disorder
• Patients allergic to Abiraterone or any of the excipients
• People not prescribed this medication—never take without medical supervision

Regulatory Status

• Prescription-only medication
• Approved by the FDA and EMA as a generic alternative to Zytiga
• Manufactured according to cGMP and international pharmaceutical standards

🔹 FAQs – Abiraterone Acetate Tablets 500 Mg

1. What is Abiraterone Acetate 500 Mg used for?
It is used to treat metastatic castration-resistant prostate cancer (mCRPC), typically in adult men and often in combination with prednisone.

2. How is the 500 Mg dose different from the 250 Mg?
The 500 mg formulation allows for a reduced pill burden, making daily treatment more convenient without compromising efficacy.

3. Is Abiraterone Acetate a type of chemotherapy?
No. Abiraterone is a hormone therapy, targeting androgen production rather than directly attacking cancer cells like chemotherapy.

4. Can women take Abiraterone Acetate?
No, this medication is not for use in women, especially during pregnancy or breastfeeding, as it can be harmful to an unborn baby.

5. Can I take this medicine with food?
No. Abiraterone should be taken on an empty stomach, as food can significantly increase drug absorption and increase side effects.

6. Why do I need prednisone with Abiraterone?
Prednisone helps reduce the side effects of hormone suppression, ensuring the drug works effectively with fewer complications.

7. What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember, unless it’s close to the next one. Never take a double dose to make up for the missed one.

8. Are there any drug interactions I should know about?
Yes. Abiraterone can interact with blood pressure meds, diabetes drugs, and steroids. Always inform your doctor about all medications you are currently taking.

9. How long do I have to take Abiraterone?
The duration depends on how well your body responds and how the cancer is progressing. Regular scans and blood tests determine how long you should continue.

10. Where can I buy Abiraterone Acetate Tablets 500 Mg?
You can purchase it from licensed pharmacies or hospitals with a valid prescription. Always choose reputable sources for quality assurance.