Description

Pazopanib Tablets 200 Mg

Pazopanib Tablets 200 Mg are prescribed for the treatment of specific advanced cancers. They are classified as a tyrosine kinase inhibitor (TKI), which works by blocking the activity of abnormal proteins that signal cancer cells to grow and divide. This medication is most commonly prescribed to treat adults with advanced renal cell carcinoma and advanced soft tissue sarcoma.

Key Uses

• First-line treatment for advanced renal cell carcinoma (RCC)
• Treatment of advanced soft tissue sarcoma (STS) after prior chemotherapy

Mechanism of Action
Pazopanib Tablets 200 Mg function by inhibiting multiple cellular receptors involved in cancer growth, including VEGFR (vascular endothelial growth factor receptors), PDGFR (platelet-derived growth factor receptors), and c-Kit. By targeting these receptor pathways, this drug prevents the formation of blood vessels that tumors need to grow and spread, ultimately slowing the progression of cancer.

Dosage and Administration

• Strength: 200 mg
• Route: Oral
• Recommended Dose: 800 mg once daily (usually 4 tablets of 200 mg)
• Administration: Taken on an empty stomach, at least one hour before or two hours after eating

Pazopanib should be swallowed whole with water, without crushing or splitting the tablet. Dosage may be adjusted by your doctor based on your response and tolerance to treatment.

Clinical Benefits

• Targets tumor growth pathways
• Inhibits angiogenesis (formation of tumor blood supply)
• Oral administration for convenient cancer care
• Shown to improve progression-free survival in clinical trials
• Used globally under brand names like Votrient

Common Side Effects

• Nausea
• Diarrhea
• Fatigue
• High blood pressure
• Hair discoloration
• Loss of appetite

Serious Side Effects

• Liver toxicity
• Heart rhythm problems
• GI perforation
• Bleeding
• Proteinuria
• Myocardial infarction

Routine monitoring of liver function, blood pressure, and cardiac health is usually required during treatment with Pazopanib Tablets 200 Mg.

Precautions and Warnings

• Not recommended during pregnancy or breastfeeding
• May interact with CYP3A4 inhibitors or inducers (such as clarithromycin or rifampin)
• Caution is required in patients with liver impairment
• Avoid consuming grapefruit or grapefruit juice
• Inform your doctor of all other medications and supplements

Drug Interactions
Pazopanib interacts with drugs that affect liver enzymes, particularly the CYP3A4 pathway. Taking it with certain medications can either reduce its effectiveness or increase side effect risks. Your oncologist should evaluate all ongoing medications before starting Pazopanib Tablets 200 Mg.

Storage Instructions

• Store below 30°C
• Protect from light and moisture
• Keep tablets in the original packaging
• Keep out of reach of children

FAQs

1. What is Pazopanib Tablets 200 Mg used for?
   Pazopanib Tablets 200 Mg are used to treat advanced kidney cancer (renal cell carcinoma) and certain types of soft tissue sarcoma in adults.
2. Is Pazopanib a chemotherapy drug?
   No, Pazopanib is a targeted therapy known as a tyrosine kinase inhibitor. It is not a traditional chemotherapy agent.
3. How should I take Pazopanib Tablets 200 Mg?
   It should be taken once daily on an empty stomach, at least one hour before or two hours after eating, and swallowed whole with water.
4. Can I take it with food?
   No, food can significantly alter the absorption of Pazopanib. Always take it on an empty stomach unless otherwise instructed.
5. What are the common side effects?
   The most commonly reported side effects include nausea, diarrhea, fatigue, hypertension, and changes in hair color.
6. Can Pazopanib Tablets 200 Mg cure cancer?
   It is not a cure but helps manage advanced cancers by slowing disease progression and improving survival time and quality of life.
7. Can I use Pazopanib while pregnant?
   No, Pazopanib may harm an unborn child. It is strongly advised to avoid pregnancy during and after treatment as recommended by your doctor.
8. Do I need regular tests during treatment?
   Yes, regular blood tests, liver function tests, blood pressure monitoring, and potentially ECGs may be required to monitor your safety during treatment.
9. What should I do if I miss a dose?
   If you miss a scheduled dose, take it as soon as you remember unless it is close to your next dose. Do not take two doses at once.
10. Can I drink alcohol while taking Pazopanib Tablets 200 Mg?
    Alcohol should be limited or avoided, especially because it may increase the risk of liver toxicity.