Mirabegron & Silodosin Capsules 25/8 Mg

Mirabegron & Silodosin Capsules 25/8 Mg is a prescription combination medicine designed to assist in the management of urinary symptoms associated with overactive bladder (OAB) and benign prostatic hyperplasia (BPH) in adult patients. It combines Mirabegron 25 mg, a β3-adrenergic receptor agonist that increases bladder storage capacity, with Silodosin 8 mg, a selective α1-adrenergic blocker that relaxes smooth muscle in the prostate and bladder neck, helping to improve urinary flow and reduce obstruction.

How Mirabegron & Silodosin Capsules 25/8 Mg Work

Mechanism of Action

• Mirabegron: Activates β3-adrenergic receptors in bladder smooth muscle, increasing bladder storage capacity and reducing urgency and frequency of urination.

• Silodosin: Selectively blocks α1-adrenergic receptors in the prostate, bladder neck, and urethra, relaxing muscle tissue and improving urinary flow while reducing prostatic obstruction.

• Combined, these actions provide symptomatic relief in patients with OAB and BPH when prescribed by a healthcare professional.

This dual mechanism helps address both storage and outflow symptoms of urinary dysfunction.

Uses of Mirabegron & Silodosin Capsules 25/8 Mg

Therapeutic Indications

Mirabegron & Silodosin Capsules 25/8 Mg are prescribed for:

• Management of urinary symptoms associated with benign prostatic hyperplasia (BPH)

• Relief of overactive bladder (OAB) symptoms such as urgency, frequency, and urge incontinence

• Improvement in urinary flow rate

• Reduction in incomplete bladder emptying

Dosage and Administration

The dosage and duration should be individualized based on clinical assessment and therapeutic response by a healthcare provider.The dosage of Mirabegron & Silodosin Capsules 25/8 Mg should be determined by a qualified healthcare provider based on the patient’s condition and response to treatment.
In some cases, clinicians may recommend Mirabegron 50 mg tablets – monotherapy option for patients who do not require combination therapy or who need treatment adjustment.

Administration Guidelines

• Take once daily with or without food

• Swallow the capsule whole with water

• Do not crush, chew, or break the capsule

• Adhere to the prescribed schedule and never adjust doses without consulting your doctor

For detailed clinical guidance, refer to Mirabegron extended-release tablets medical information from a trusted medical source.

Side Effects

As with any medication, side effects can occur. Patients should discuss any concerns with their healthcare provider.Patients can review Silodosin drug information – MedlinePlus –Official safety and side effect reference for comprehensive details on possible side effects, drug interactions, and safety warnings.

Common Side Effects

• Dizziness

• Headache

• Nasal congestion

• Abnormal ejaculation

• Urinary tract infection

• Dry mouth

Less Common Side Effects

• Orthostatic hypotension (sudden drop in blood pressure upon standing)

• Palpitations

• Constipation or diarrhea

• Tiredness

Report severe or persistent symptoms to a healthcare professional.

Warnings and Precautions

Before starting this medication, patients should inform their healthcare provider of any medical history.Patients and clinicians should review Mirabegron extended-release tablets medical information –

Trusted prescribing and safety data to understand contraindications, safety precautions, and clinical monitoring recommendations.

Important Safety Information

• Not recommended for pediatric use

• Use with caution in patients with severe liver or kidney impairment

• Avoid if allergic to Mirabegron, Silodosin, or similar medicines

• Alcohol may enhance dizziness or low blood pressure effects

• Use during pregnancy or breastfeeding only if prescribed by a clinician

Storage Instructions

• Store at room temperature below 25°C

• Protect from moisture and direct sunlight

• Keep out of reach of children

• Retain in original packaging until use

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