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Temistaran + Hydrochlorothiazide Tablets

Temistaran and Hydrochlorothiazide are used together in a combination tablet to treat high blood pressure (hypertension). This combination leverages the complementary actions of both medications to effectively manage blood pressure.

Composition:

• Temistaran: An angiotensin II receptor blocker (ARB) that helps relax blood vessels and lower blood pressure by blocking the action of angiotensin II, a substance that causes blood vessels to constrict.
• Hydrochlorothiazide: A thiazide diuretic that helps reduce blood pressure by removing excess fluid from the body and decreasing blood volume.

Key Uses:

• Hypertension (High Blood Pressure): This combination is used to manage and lower high blood pressure, reducing the risk of stroke, heart attack, and kidney problems.
• Combination Therapy: Often prescribed when a single medication does not adequately control blood pressure. The combination can be more effective than either drug alone.

Administration and Dosage:

• Oral Administration: Taken orally, usually once daily, with or without food.
• Dosage: The dosage varies based on the specific formulation and patient response. A common starting dose is 40 mg of Temistaran and 12.5 mg of Hydrochlorothiazide once daily, which can be adjusted by the healthcare provider.

Important Considerations:

• Side Effects: Common side effects include dizziness, headache, fatigue, and gastrointestinal discomfort. Serious side effects may include electrolyte imbalances (such as low potassium or sodium levels), dehydration, and kidney dysfunction.
• Monitoring: Regular monitoring of blood pressure, kidney function, and electrolyte levels is essential during treatment. Adjustments to the dosage may be needed based on the patient’s response and any side effects.
• Contraindications: Not suitable for patients with severe kidney impairment, anuria (inability to urinate), or those who are pregnant or breastfeeding. Caution is required in patients with a history of gout, diabetes, or liver disease.
• Drug Interactions: This combination can interact with other medications, including other antihypertensives, potassium supplements, and non-steroidal anti-inflammatory drugs (NSAIDs). Inform your healthcare provider about all medications and supplements you are taking.
• Pregnancy and Breastfeeding: Generally avoided during pregnancy due to potential risks to the fetus. It is not recommended for use while breastfeeding.
• Prescription Only: Available by prescription only and should be used under the supervision of a healthcare provider.

Similar Brand Names:

• Cozaar-HCT (American Brand Name for a similar combination)