Sitagliptin & Metformin Tablets 100/1000 Mg

Janumet is an oral medication used to manage type 2 diabetes. It combines two active ingredients: sitagliptin and metformin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, while metformin is a biguanide. Together, they work to improve blood sugar control by increasing insulin release, decreasing glucagon levels, and improving insulin sensitivity.

Composition:

• Sitagliptin: Enhances the body’s natural ability to control blood sugar levels.
• Metformin: Decreases glucose production in the liver and improves insulin sensitivity.

Key Uses:

• Type 2 Diabetes Management: Janumet is used to improve glycemic control in adults with type 2 diabetes as an adjunct to diet and exercise.

Administration and Dosage:

• Oral Administration: Taken orally, typically twice daily with meals to reduce gastrointestinal side effects.
• Dosage: The dosage depends on the patient’s current regimen, effectiveness, and tolerability. Common dosages include 50 mg sitagliptin / 500 mg metformin or 50 mg sitagliptin / 1000 mg metformin taken twice daily. Dosage adjustments may be required based on renal function.

Important Considerations:

• Side Effects: Common side effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. Other side effects may include upper respiratory tract infection, headache, and nasopharyngitis. Serious side effects can include lactic acidosis, pancreatitis, and severe joint pain.
• Monitoring: Regular monitoring of blood sugar levels is essential to ensure the medication’s effectiveness and to avoid hypoglycemia. Kidney function should also be monitored periodically due to the metformin component.
• Contraindications: Not suitable for patients with severe renal impairment, metabolic acidosis (including diabetic ketoacidosis), or a history of serious hypersensitivity to sitagliptin. Use with caution in patients with a history of pancreatitis.
• Drug Interactions: Janumet can interact with other medications, including other antidiabetic drugs, ACE inhibitors, diuretics, and certain medications that affect renal function. Inform your healthcare provider about all medications and supplements you are taking.
• Pregnancy and Breastfeeding: The safety of Janumet during pregnancy and breastfeeding has not been established. It should only be used if clearly needed and prescribed by a healthcare provider.
• Diet and Lifestyle: Janumet should be used as part of a comprehensive treatment plan that includes dietary changes, regular physical activity, and weight management.
• Prescription Only: Available by prescription only and should be used under the supervision of a healthcare provider.

Similar Brand Names:

• Janumet XR (Extended-release formulation)
• Kombiglyze XR (Contains saxagliptin and metformin)