Description

Dasatinib Tablets 70 mg

Dasatinib Tablets 70 mg is a prescription oral medication used in the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is a tyrosine kinase inhibitor (TKI) that works by blocking the abnormal BCR-ABL enzyme responsible for the uncontrolled growth of cancerous white blood cells.

Dasatinib is often used in patients who are newly diagnosed or who have developed resistance or intolerance to prior therapies like imatinib. It is available under the brand name Sprycel and also in generic form.

The 70 mg strength is typically used for Ph+ ALL or advanced phase CML (accelerated or blast crisis) and may be integrated into a patient’s dosage schedule depending on tolerance, age, weight, and clinical response.

Therapeutic Indications

Dasatinib 70 mg is indicated for:

• Treatment of adults with chronic, accelerated, or blast phase chronic myeloid leukemia (CML) with the Philadelphia chromosome-positive (Ph+)
• Treatment of Ph+ acute lymphoblastic leukemia (Ph+ ALL) in adults
• Pediatric use in Ph+ CML and Ph+ ALL (dose adjusted individually)

Mechanism of Action

Dasatinib inhibits BCR-ABL1 kinase, the abnormal protein causing uncontrolled growth in leukemia cells. It also blocks other kinases such as:

• SRC family kinases
• c-KIT
• PDGFR
• EPHA2

This stops the signal processes that promote cancer cell survival and division, making the drug effective even in imatinib-resistant cases.

Dosage and Administration

• Strength: 70 mg per tablet
• Common Adult Doses:
  • Ph+ ALL: 140 mg once daily (70 mg may be used twice a day)
  • Accelerated or blast phase CML: 140 mg (divided as 70 mg twice daily)
• Route: Oral
• Administration: Can be taken with or without food
• Swallow whole with water — do not crush, split, or chew

Note: Dosage is individualized. Pediatric dosing is calculated based on body surface area or weight.

Composition

• Active Ingredient: Dasatinib 70 mg
• Dosage Form: Film-coated tablet
• Packaging: Usually in blister packs or HDPE bottles (10, 28, or 30 tablets)

Common Side Effects

• Headache
• Nausea or vomiting
• Diarrhea
• Fatigue
• Rash
• Fluid retention or edema
• Decreased white blood cells or platelets

Serious Side Effects

• Pleural effusion (fluid around lungs)
• Severe myelosuppression
• QT prolongation (irregular heartbeat)
• Liver toxicity
• Blood clots
• Hemorrhagic (bleeding) events
• Infections

Patient must be monitored regularly for blood counts, liver function, and fluid balance.

Contraindications and Precautions

• Contraindicated in patients with hypersensitivity to Dasatinib
• Not recommended for pregnant or breastfeeding women
• Avoid use in patients with uncontrolled cardiovascular conditions
• Monitor liver and kidney function during treatment
• Use caution in patients with bleeding disorders
• Avoid concomitant use with strong CYP3A4 inhibitors or inducers

Routine ECGs and blood tests are often required to monitor for side effects during the treatment course.

Storage Conditions

• Store below 25°C
• Keep in original packaging to protect from moisture and light
• Keep out of reach of children

Frequently Asked Questions (FAQs)

1. What is Dasatinib 70 mg used for?
It is used to treat chronic myeloid leukemia (CML) and Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) in adults and pediatric patients.

2. Is 70 mg a standard dose?
70 mg is often used twice daily in combination regimens, especially in Ph+ ALL or patients in advanced phases of CML.

3. Can I take Dasatinib with food?
Yes, it can be taken with or without food, but at the same time each day for best results.

4. How long is Dasatinib treatment continued?
Treatment continues as long as it is effective and tolerable. Decisions are made by an oncologist based on disease status.

5. What are the common side effects?
Common side effects include nausea, fatigue, headache, fluid retention, and lowered blood counts.

6. Can Dasatinib cure leukemia?
It does not cure leukemia but helps manage the disease, control symptoms, and prevent progression.

7. Can pregnant women take Dasatinib?
No. Dasatinib should not be used during pregnancy due to high risk of fetal harm.

8. Is there a generic version of Dasatinib 70 mg?
Yes, generic Dasatinib is available in many countries at lower cost alternatives to brand-name Sprycel.

9. How should I store it?
Store below 25°C, protected from moisture, heat, and light.

10. Do I need a prescription to buy Dasatinib?
Yes. Dasatinib is a high-risk medication that must be prescribed and monitored by a healthcare provider.