Description

Axitinib Tablets 5 mg

Overview

Axitinib Tablets 5 mg is an oral, potent tyrosine kinase inhibitor (TKI) used for the treatment of advanced renal cell carcinoma (RCC), the most common form of kidney cancer in adults. It works by inhibiting vascular endothelial growth factor receptors (VEGFR 1, 2, 3), cutting off the blood supply needed for cancer cells to grow and spread. This medication is typically used after disease progression following previous treatments such as sunitinib or cytokine therapy.

Axitinib 5 mg is commonly known by the brand Inlyta, and generic forms are now available at more affordable prices.

Therapeutic Classification

• Drug Class: VEGFR Inhibitor
• Type: Targeted anticancer therapy (TKI)
• Route: Oral

Uses and Indications

Axitinib 5 mg is indicated for:

• Advanced renal cell carcinoma (RCC) in adults
• Second-line treatment when the disease worsens after 1 prior systemic therapy
• As part of combination therapy with immunotherapy in selected clinical protocols

Unapproved use outside the approved condition should be guided strictly by oncologists.

Mechanism of Action

Axitinib selectively blocks VEGFR 1, 2, and 3, proteins that help cancer tumors grow new blood vessels (angiogenesis). By inhibiting these, Axitinib:

• Reduces blood supply to tumors
• Slows or halts tumor progression
• May improve survival and delay relapse

Since RCC is a highly vascular tumor, Axitinib plays a critical role in reducing tumor nourishment.

Dosage and Administration

• Standard Dose: 5 mg orally twice daily
• Dosing Interval: Every 12 hours (approx.)
• Duration: Until disease progression or unacceptable toxicity
• Administration: With or without food, swallow tablets whole

Dose adjustments may be required based on patient tolerance, organ function, or side effects.

Composition

• Active Ingredient: Axitinib 5 mg per tablet
• Inactive Ingredients: Microcrystalline cellulose, lactose, magnesium stearate, povidone K-30
• Tablet Color: Generally red or pink (varies by brand)
• Available Packaging: Strips or bottles of 14 or 28 tablets

Storage Instructions

• Store at 20°C to 25°C (68°F to 77°F)
• Keep in the original container
• Protect from light, moisture, and extreme temperatures
• Keep out of reach of children and pets

Common Side Effects

Like all cancer medications, Axitinib may cause side effects which vary from person to person.

Common Effects Include:

• Hypertension (high blood pressure)
• Diarrhea
• Fatigue
• Nausea
• Decreased appetite
• Hoarseness
• Hand-Foot Syndrome (skin reaction on palms/soles)
• Weight loss

Serious Adverse Effects (Seek immediate medical attention)

• Blood clots (deep vein thrombosis, pulmonary embolism)
• Liver damage
• Bleeding symptoms
• Heart conditions
• Severe diarrhea or dehydration
• Gastrointestinal perforation (rare)

Warnings and Precautions

• Pregnancy Category D: Can cause fetal harm. Avoid during pregnancy.
• Breastfeeding: Not recommended
• Regular monitoring of blood pressure, renal/liver function, and thyroid function is crucial.
• May need to be paused before surgery
• Do not take with strong CYP3A4 inducers or inhibitors without medical clearance

Contraindications

• Hypersensitivity to Axitinib
• Uncontrolled high blood pressure
• Severe liver or cardiac illness (consult prescriber)

Drug Interactions

Do not take Axitinib with the following unless advised:

• Ketoconazole or Rifampicin
• St. John’s Wort
• Warfarin or other anticoagulants
• Medications affecting liver enzymes (CYP3A4)

Who Should Use It

• Adults with a diagnosis of advanced or metastatic RCC
• Patients who have progressed after VEGF-targeting therapy
• Under direct supervision of an oncologist

Frequently Asked Questions (FAQs)

1. What is Axitinib 5 mg used for?
It is used for treating advanced renal cell carcinoma (kidney cancer) in adults, especially after failure of prior therapy.

2. Is Axitinib a chemotherapy drug?
No, it is a targeted therapy. It works by cutting off the blood flow to tumors rather than killing cells directly like chemotherapy.

3. How is Axitinib taken?
Twice a day by mouth, with or without food. Your doctor will provide dosing schedules.

4. How long can I take Axitinib?
As long as it is effective and tolerated without severe side effects. Treatment continues until progression or intolerance.

5. What are the most common side effects?
High blood pressure, fatigue, diarrhea, sore throat, and loss of appetite.

6. Can I drink alcohol with Axitinib?
Alcohol may increase the risk of liver damage or worsen certain side effects. Consult your doctor.

7. Can I take Axitinib during pregnancy?
No. It can harm an unborn baby. Avoid pregnancy during treatment and for at least a week after the final dose.

8. How is Axitinib stored?
Keep it in its original packaging, at room temperature, protected from heat and light.

9. Will my blood pressure need monitoring?
Yes. Hypertension is one of the most common side effects and needs regular monitoring.

10. Can I buy Axitinib 5 mg online?
Yes, from licensed and certified pharmacies with a valid prescription.