Ethambutol Tablets 400 Mg

What Is Ethambutol Tablets 400 Mg?

Ethambutol is an antitubercular antibiotic that acts by interfering with the synthesis of the mycobacterial cell wall. It is classified as bacteriostatic, meaning it inhibits bacterial growth rather than directly killing the bacteria. Ethambutol is typically used in combination with other antitubercular drugs such as isoniazid, rifampicin, and pyrazinamide.

Ethambutol Tablets 400 mg are commonly used in adults and are part of standard first-line therapy for both pulmonary and extrapulmonary TB, as determined by a clinician.

How Ethambutol Works

Ethambutol works by disrupting the formation of arabinogalactan, a key component of the TB bacterium’s cell wall. This increases cell wall permeability and slows bacterial growth, enhancing the effectiveness of companion drugs in the treatment regimen.

Indications

Ethambutol Tablets 400 mg are indicated for:

• Pulmonary tuberculosis

• Extrapulmonary tuberculosis

• As part of combination antitubercular therapy

Ethambutol should not be used alone due to a high risk of drug resistance. Proper use requires clinical assessment and prescription by a qualified healthcare provider.

Dosage & Administration

• Typical adult dose: 400 mg once daily (dose may vary based on body weight and physician direction)

• Administer with a full glass of water

• Can be taken with or without food as advised by a clinician

• Complete the full course as prescribed — do not stop therapy early

The exact dosing schedule and duration are determined by a medical professional based on age, weight, severity of infection, and treatment response.

Safety Information & Important Precautions

Before using Ethambutol Tablets 400 mg, tell your healthcare provider if you have:

• A history of eye or vision problems

• Kidney disease

• Elevated levels of uric acid or history of gout

• Allergies to ethambutol or related medications

Vision Monitoring

One important safety consideration is the potential impact on the optic nerve. Patients should have visual acuity and colour vision tested before starting ethambutol and periodically during treatment. Report any changes in vision — such as blurred vision or inability to distinguish colours — immediately.

Ethambutol may also interact with other medications, including antacids (e.g., aluminum-containing products), which can reduce absorption if taken too close together. Always consult your clinician about timing and possible interactions.

Common Side Effects

Possible side effects may include:

• Changes in vision (blurred vision or colour perception changes)

• Headache

• Dizziness

• Loss of appetite

• Nausea

• Joint pains

Most side effects are mild. Seek medical help if you experience severe visual changes, persistent headache, or neurological symptoms.

Drug Interactions

Ethambutol may interact with:

• Antacids containing aluminum

• Other agents used in tuberculosis treatment

• Supplements that affect uric acid levels

Always disclose all current medications, vitamins, and supplements to your healthcare provider.

Storage Instructions

Store Ethambutol Tablets 400 mg in a cool, dry place at room temperature, away from moisture and direct sunlight. Keep medicine out of reach of children.

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