Tamsulosin & Dutasteride Capsules 0.4/0.5 Mg

Tamsulosin & Dutasteride Capsules 0.4/0.5 mg

Benign prostatic hyperplasia (BPH) is a condition in which the prostate gland enlarges, leading to lower urinary tract symptoms (LUTS) such as weak urine stream, urgency, frequency, and incomplete bladder emptying.

This formulation combines:

• Tamsulosin 0.4 mg – a selective alpha-1A blocker that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow.

• Dutasteride 0.5 mg – a 5-alpha-reductase inhibitor that decreases the conversion of testosterone to dihydrotestosterone (DHT), helping reduce prostate volume over time.

Together, they address both functional obstruction and prostate enlargement, helping to improve symptoms and reduce the risk of BPH progression.

How the Combination Works

Tamsulosin Mechanism

Tamsulosin acts on alpha-1A receptors in the lower urinary tract, causing relaxation of smooth muscle in the bladder neck and prostate. This decreases resistance to urine flow and reduces symptoms like urgency and weak stream.

Dutasteride Mechanism

Dutasteride blocks both type 1 and type 2 5-alpha-reductase enzymes, preventing the conversion of testosterone to dihydrotestosterone (DHT), a hormone linked to prostate growth. This can:

• Reduce prostate size

• Improve urinary symptoms related to gland enlargement

• Lower the likelihood of requiring surgery

Medical Uses

Tamsulosin & Dutasteride Capsules 0.4/0.5 mg are prescribed for:

• Benign prostatic hyperplasia (BPH)

• Lower urinary tract symptoms (LUTS) related to BPH

• Long-term management of prostate enlargement

• Improving urine flow and reducing BPH symptom severity

This combination is most appropriate for men with moderate to severe BPH or those at higher risk of disease progression.

Dosage & Administration

• Usual dose: One capsule once daily

• May be taken with or without food

• Swallow the capsule whole; do not crush or chew

Your healthcare professional will adjust the dose based on clinical evaluation, symptom severity, and response. Adherence to prescribed dosing and regular follow-up are recommended.

Safety Information & Precautions

Before taking this medication:

• Inform your healthcare provider about any allergies, liver or kidney disease.

• Discuss history of low blood pressure, eye surgery (especially cataract surgery), or fainting episodes.

• Dutasteride may affect sexual function in some individuals; report any changes to your clinician.

Important Notes

• Women, especially those who are or could become pregnant, should not handle crushed or broken capsules due to risk to the male fetus.

• This medication is intended only for adult men diagnosed with BPH.

Possible Side Effects

Common side effects may include:

• Dizziness or lightheadedness

• Headache

• Erectile dysfunction or decreased libido

• Ejaculatory disorders

• Nasal congestion

Most side effects are mild and may lessen with continued use. If you experience severe symptoms such as fainting, persistent dizziness, severe erection issues, or allergic reactions, seek medical advice.

Drug Interactions

Tamsulosin & Dutasteride Capsules may interact with:

• Other alpha blockers

• Antihypertensive medications

• CYP3A4 inhibitors (affecting tamsulosin metabolism)

• Concurrent hormonal therapies

Inform your healthcare provider about all prescription and non-prescription medicines you are taking.

Storage Instructions

Store in a cool, dry place below 25°C, away from moisture, heat, and direct sunlight. Keep out of reach of children and pets.

FAQs