Spironolactone Tablets 50 Mg

Spironolactone Tablets 50 mg

Spironolactone is a potassium-sparing diuretic that inhibits the action of the hormone aldosterone on renal tubules. Aldosterone promotes sodium and water retention; by blocking its effect, spironolactone increases the excretion of sodium and water while reducing potassium loss. This unique action makes it valuable in specific conditions where fluid overload or hormonal imbalance contributes to symptoms.

How Spironolactone Works

Spironolactone competitively antagonizes aldosterone receptors in the distal renal tubule. This results in:

• Enhanced excretion of sodium and water

• Reduced excretion of potassium

• Lowered fluid volume in congestive states

• Decrease in blood pressure in selected patients

Because it conserves potassium, spironolactone is often used in combination with other diuretics that can cause potassium depletion.

Indications

Spironolactone Tablets 50 mg are indicated for:

• Edema due to heart failure

• Edema associated with liver cirrhosis

• Edema from kidney disorders

• Hypertension (high blood pressure), especially when resistant or requiring combination therapy

• Management of primary hyperaldosteronism (as determined by a clinician)

Clinical assessment and monitoring are essential due to the potential for electrolyte changes.

Dosage & Administration

The dosage of Spironolactone Tablets 50 mg varies by condition and patient response:

• Typically taken once daily with or without food

• Do not crush or split tablets unless directed

• Dose adjustments are based on clinical response and laboratory monitoring

Healthcare professionals tailor doses based on the severity of symptoms, kidney function, and serum potassium levels.

Safety Information & Precautions

Before using spironolactone, inform your healthcare provider if you have:

• High potassium levels (hyperkalemia)

• Renal impairment

• Liver disease or cirrhosis

• Adrenal insufficiency

• A history of allergy to spironolactone or similar medications

Important Safety Notes

• Regular monitoring of serum electrolytes (especially potassium) and renal function is recommended.

• Spironolactone may interact with other potassium-sparing agents or supplements, increasing the risk of hyperkalemia.

• Patients should be advised to avoid high-potassium diets or potassium supplements unless directed.

Common Side Effects

Side effects may include:

• Hyperkalemia (high potassium)

• Nausea or vomiting

• Headache

• Fatigue

• Dizziness

• Breast tenderness or enlargement (rare)

If severe symptoms such as muscle weakness, arrhythmia, or fainting occur, seek medical attention promptly.

Drug Interactions

Spironolactone may interact with:

• ACE inhibitors or ARBs (may increase potassium)

• Other diuretics

• NSAIDs

• Potassium supplements

• Certain antibiotics

Always disclose all medications and supplements to your healthcare provider.

Storage Instructions

Store Spironolactone Tablets 50 mg in a cool, dry place below 25°C, away from direct sunlight and moisture. Keep out of reach of children and pets.

FAQs