Description

Olaparib Tablets 100 mg

Overview

Olaparib Tablets 100 mg are a breakthrough oncology solution specifically formulated for patients with certain types of advanced or recurrent cancers. Belonging to a class of drugs known as PARP inhibitors, Olaparib targets cancer at the DNA level, preventing tumor cells from repairing their damaged genetic material. This mode of action slows or stops the spread of cancer cells, making it a powerful tool in cancer therapy.

Olaparib is widely prescribed for patients with BRCA-mutated ovarian, breast, metastatic pancreatic, and prostate cancers. It is an oral formulation, allowing patients to manage their treatment in the comfort of their homes under medical supervision.

Manufactured by leading pharmaceutical companies under stringent quality standards, Olaparib Tablets 100 mg have been clinically validated for safety and efficacy through numerous global trials.

What is Olaparib?

Olaparib is an oral drug classified as a PARP (Poly ADP-ribose polymerase) inhibitor. PARP enzymes help repair DNA damage in cells; however, in cancer cells with BRCA1/BRCA2 gene mutations, the normal DNA repair mechanism is already faulty. Olaparib blocks PARP’s activity, causing cancerous cells to accumulate damage and eventually die — all while sparing normal cells.

Indications & Usage

Olaparib 100 mg is indicated for the treatment of:

• Advanced Ovarian Cancer: Especially after at least two prior lines of chemotherapy in patients with germline BRCA mutations.
• HER2-Negative Breast Cancer: For patients with BRCA1/2 mutations and previously treated metastatic breast cancer.
• Metastatic Pancreatic Cancer: With confirmed BRCA gene mutation and after platinum-based chemotherapy.
• Prostate Cancer: In patients with BRCA1/2 or ATM gene mutations previously treated with hormonal therapy or chemotherapy.

These uses are subject to regional approval by medical regulatory bodies like the FDA, EMA, and other national health agencies.

Mechanism of Action

Olaparib works by inhibiting PARP enzymes involved in DNA repair. BRCA-mutated cancer cells rely heavily on PARP to survive. By blocking PARP, Olaparib causes accumulated DNA damage in these cells, leading to their destruction through a process called synthetic lethality.

This precision-targeted therapy minimizes the effect on healthy tissue, resulting in fewer side effects compared to traditional chemotherapy.

Dosage and Administration

• Strength: 100 mg tablets (also available in 150 mg)
• Route: Oral
• Typical Dosage: 300 mg per day (can be given as 2 x 150 mg or 3 x 100 mg tablets, twice daily)
• Administration Tips:
  • Take whole with water; do not crush or chew.
  • Can be taken with or without food.
  • Maintain a consistent schedule for optimal results.

Always follow the dosing regimen prescribed by your oncologist. Dosage may be adjusted based on tolerance, organ function, or other ongoing medical therapies.

Benefits of Olaparib Tablets 100 mg

• Targeted Cancer Therapy – Specifically attacks cancer cells with BRCA1/2 mutations.
• Oral Convenience – No need for hospital-based IV infusions.
• Proven Clinical Effectiveness – Stalls tumor progression and increases progression-free survival.
• Used as Maintenance Therapy – Helps prevent cancer recurrence in remission patients.
• Favorable Side Effect Profile – Compared to traditional chemotherapy.

Side Effects

Though generally well tolerated, some patients may experience side effects such as:

• Nausea or vomiting
• Fatigue or weakness
• Anemia or decreased blood counts
• Headache
• Loss of appetite
• Respiratory tract infections

Discuss any side effects with your healthcare provider. Monitoring through blood tests is recommended during therapy.

Interactions & Warnings

• Drug Interactions: May interact with CYP3A inhibitors and inducers (e.g., ketoconazole, rifampin).
• Contraindications: Not recommended in patients with known hypersensitivity to Olaparib.
• Pregnancy Risk: Not safe during pregnancy or for women planning to become pregnant.
• Breastfeeding: Discontinue or avoid breastfeeding while taking the drug and for a certain period after the last dose.

Always inform your doctor about any other supplements, medicines, or herbal products you are taking.

Storage Guidelines

• Store in a cool, dry place below 25°C (77°F)
• Protect from moisture and direct sunlight
• Keep out of reach of children and pets

Why Choose Olaparib?

Choosing Olaparib means opting for scientifically backed, precision-targeted cancer treatment. It offers hope to cancer patients by increasing their chances of remission, with a manageable side-effect profile and enhanced quality of life.

Whether you’re starting first-line maintenance therapy or exploring alternative options in relapsed cancers, Olaparib Tablets 100 mg are becoming increasingly recommended by oncology experts worldwide.

10 Frequently Asked Questions (FAQs)

1. What is Olaparib used for?

Olaparib is used primarily to treat cancers linked to BRCA gene mutations, including ovarian, breast, prostate, and pancreatic cancers.

2. How does Olaparib help treat cancer?

Olaparib inhibits the PARP enzyme, preventing BRCA-mutated cancer cells from repairing their DNA, which leads to cell death.

3. Is Olaparib a form of chemotherapy?

No, Olaparib is not traditional chemotherapy. It is a targeted therapy, designed to selectively impact cancer cells.

4. Can I take Olaparib if I do not have a BRCA mutation?

It is most effective in patients with BRCA mutations. Genetic testing is usually performed to confirm eligibility.

5. What should I avoid while taking Olaparib?

Avoid grapefruit juice and strong CYP3A inhibitors or inducers unless approved by your doctor. Do not become pregnant while on this medication.

6. Can I take Olaparib with food?

Yes, it can be taken with or without food. However, try to remain consistent with how you take your dose daily.

7. What should I do if I miss a dose?

Skip the missed dose if it’s nearly time for the next one. Do not double up on doses. Always consult your doctor for personalized instructions.

8. How long is Olaparib treatment?

Duration depends on cancer type, stage, and response to therapy. Some patients take it long-term as maintenance therapy.

9. Are there alternatives to Olaparib?

Yes, other PARP inhibitors like Talazoparib (Talzenna) and Niraparib (Zejula) exist. Your oncologist will guide the best option for your condition.

10. Can men take Olaparib?

Yes. Olaparib is effective in treating male patients, particularly those with metastatic castration-resistant prostate cancer (mCRPC) and BRCA mutations.