Description

Pomalidomide Capsules 1 Mg

Pomalidomide Capsules 1 Mg contain the active ingredient Pomalidomide, a potent immunomodulatory agent (IMiD). This medication is prescribed to treat adults with relapsed or refractory multiple myeloma who have received at least two prior therapies, including lenalidomide and a proteasome inhibitor.

Pomalidomide also has indications for Kaposi’s sarcoma in patients with HIV (AIDS-related disease), particularly when resistance or intolerance to first-line therapy is a concern.

The use of Pomalidomide Capsules 1 Mg is strictly regulated due to its known risk of serious birth defects. It should only be prescribed, dispensed, and taken under a specialized Risk Evaluation and Mitigation Strategy (REMS) program.

Indications and Uses

Pomalidomide Capsules 1 Mg are FDA-approved for:

• Multiple Myeloma (relapsed or refractory) in adult patients who have received at least two prior treatments, including lenalidomide and a proteasome inhibitor.
• Kaposi’s Sarcoma:
  • Treatment of AIDS-related Kaposi’s sarcoma after failure of antiretroviral therapy.
  • Classical Kaposi’s sarcoma in HIV-negative patients.

Pomalidomide is typically used in combination with dexamethasone or other anti-cancer agents, depending on the condition being treated.

How Pomalidomide Works

Pomalidomide is a third-generation immunomodulatory drug (IMiD). It works through multiple pathways to control the growth and spread of cancer cells:

• Enhances T-cell and natural killer (NK) cell activity, boosting the body’s immune response.
• Inhibits angiogenesis, cutting off blood supply to cancer cells.
• Reduces the production of pro-inflammatory cytokines, which are associated with tumor growth.
• Interferes directly with cellular pathways that allow myeloma cells to survive.

Because of its multitargeted effects, Pomalidomide helps patients who no longer respond to previous therapies.

Dosage and Administration

Form: Capsule
Strength: 1 mg
Route: Oral

Recommended Usage:

• For multiple myeloma, Pomalidomide Capsules 1 Mg are usually taken once daily on days 1 through 21 of each 28-day cycle, in combination with dexamethasone.
• For Kaposi’s sarcoma, the dose and schedule will depend on clinical evaluation.

Administration Guidelines:

• Take the capsule at the same time each day.
• Swallow whole with water; do not open, crush, or chew.
• Can be taken with or without food.
• Strict birth control measures must be followed due to teratogenic risk.

Note: Because of potential risks, patients must be enrolled in a REMS program, and regular pregnancy tests are required for women of childbearing potential.

Benefits of Pomalidomide Capsules 1 Mg

• Effective in managing relapsed/refractory multiple myeloma
• Offers therapeutic option for Kaposi’s sarcoma resistant to antiretroviral therapy
• Reduced disease progression in advanced stages
• Well-tolerated in many patients when used under medical supervision
• Administered orally—no hospital-based infusions necessary
• Supported by major clinical studies and FDA approval

Possible Side Effects

Like most cancer therapies, Pomalidomide Capsules 1 Mg may cause side effects. Not everyone will experience them, and severity varies.

Common side effects:

• Fatigue
• Constipation
• Nausea
• Diarrhea
• Anemia
• Low white blood cell count (neutropenia)
• Infections (due to immune suppression)

Serious side effects can include:

• Deep vein thrombosis (DVT) / Pulmonary embolism (PE)
• Liver toxicity
• Severe neutropenia leading to infections
• Allergic reactions or rash
• Tumor lysis syndrome (rare)

Regular blood tests and monitoring are essential during treatment.

Precautions and Warnings

• Pomalidomide can cause severe birth defects or death of an unborn baby. Do not use during pregnancy or if trying to conceive.
• Women must use two reliable forms of birth control.
• Men must use condoms during sexual contact with women of reproductive age.
• Avoid donation of blood or sperm during and after treatment for a period specified by your doctor.
• May increase the risk of blood clots; blood thinners may be prescribed in high-risk patients.

Drug Interactions

The metabolism of Pomalidomide may be affected when taken with other medications. Inform your doctor about:

• CYP1A2 inhibitors (e.g., fluvoxamine)
• Dexamethasone (commonly co-administered)
• Immunosuppressants
• Antibiotics and antifungals
• Herbal products (e.g., St. John’s Wort)

Always share a full list of medicines and supplements you’re taking with your prescribing physician.

Storage Information

• Store at 25°C (77°F); excursions permitted between 15°C and 30°C (59°F to 86°F).
• Keep in the original blister packaging.
• Store securely and keep away from children and pets.
• Handle with care. Wash hands before and after handling capsules.

Frequently Asked Questions (FAQs)

1. What is Pomalidomide Capsules 1 Mg used for?

It is used to treat multiple myeloma and Kaposi’s sarcoma in patients who have received prior therapy.

2. Is Pomalidomide chemotherapy?

It is classified as an immunomodulatory agent, not traditional chemotherapy, but is used to treat cancer.

3. How does Pomalidomide differ from Lenalidomide?

Pomalidomide is a newer-generation IMiD and is typically used after resistance to lenalidomide has developed.

4. Can I take Pomalidomide Capsules 1 Mg during pregnancy?

No. It should never be taken during pregnancy due to the high risk of birth defects.

5. What monitoring is required during treatment?

Regular blood tests, pregnancy testing (if applicable), and doctor consultations are required.

6. Can I take this medicine with food?

Yes. Pomalidomide can be taken with or without food.

7. Are there alternatives to Pomalidomide?

Yes. Alternatives include lenalidomide, thalidomide, bortezomib, and newer agents. Your doctor will determine suitability.

8. Do I need to be part of a REMS program?

Yes. Pomalidomide is available only through a certified REMS program due to its safety risks.

9. What should I avoid during treatment?

Pregnancy, blood/sperm donation, and taking non-approved medications without consulting your doctor.

10. Can this be taken long-term?

Yes, in many cases it is taken long-term as part of maintenance therapy, depending on response and tolerance.